TABLE OF CONTENTS

INTRODUCTION

• FTase crystal structure

SUBSTRATES DOCKING

• FTase - FPP - HRAS-1 complex
• FTase - FPP main interactions
• FTase - H-RAS-1 (CVLS) main interactions

INHIBITORS DOCKING

• FTase - (S)-FPOH complex
• FTase - BZA-2B complex
• FTase - SCH-44342 complex
• FTase - Fusidienol complex
• FTase - 10'-Desmethoxystreptonigrin complex
• FTase - Zaragozic acid complex

METHODS

• Computational methods
• BioDock schematics

DISCUSSION

REFERENCES